DHEA

Posted by on in Uncategorized
  • Font size: Larger Smaller
  • Hits: 4685
  • Subscribe to this entry
  • Print

Description

Dehydroepiandrosterone (DHEA) is a steroid hormone produced in the adrenal glands, gonads (testes and ovaries), and brain.1 DHEA is often referred to as the “mother of all hormones” because it is the building block from which both male and female hormones are produced. It is synthesized in the adrenal glands, brain, and gonads, and it is locally metabolized into other steroid hormones including androstenedione, testosterone, and 17-B-estradiol (E2).1 DHEA is absorbed from the small intestine and transported to the liver to be metabolized and distributed to the various tissues where metabolites are synthesized. DHEA production declines in your mid-thirties to forties, leading to a deficiency that can make you feel mentally and physically exhausted. Exhaustion and stress are related to an increase in cortisol levels2 and DHEA’s role in countering cortisol levels is often overlooked.3,4 Cortisol is necessary for many important functions and is related to a normal stress response. When cortisol stays too high for too long, it becomes dangerous for those tissues that respond to cortisol.5 DHEA can help to bring cortisol back into balance.6 High sustained cortisol levels are known to be associated with many stress-related conditions. Given the high levels of stress everyone seems to deal with these days, it would be wise for adults of both genders to monitor their DHEA levels. Low DHEA levels can also lead to weakened immunity and increased inflammation.7

Benefits of DHEA Replacement

  • Improves function of the immune system6,8-11
  • Cognitive enhancement4,9,12
  • Increases energy
  • Reduces body fat and cholesterol13
  • Increases insulin sensitivity14
  • Potent antioxidant
  • Slows some of the effects of aging in women15
  • Improves mood4,16
  • Supports healthy bones and calcium absorption in men17,18

Side Effects

DHEA should not be used by individuals with a history of prostate, uterine, ovarian or breast cancer. Diabetics should carefully monitor blood sugar levels, as DHEA may alter glucose regulation. Use with caution in individuals with hepatic dysfunction or hypertension.

Consult your physician before supplementing with DHEA if you are taking these medications: 4-androstenedione, 4-androstenediol, 5-androstenedione, 19-4-norandrostenedione and 19-5-norandrostenediol, testosterone replacement therapy, or estrogen replacement therapy (Premarin, Estrace, etc.).

Anti-depressants: fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), citalopram (Celexa).

Medicines for seizures, certain mental disorders or pain: For example, fluphenazine (Prolixin), thorazine (Stelazine), thioridazine (Mellaril), clozapine (Clozaril), haloperidol (Haldol), risperidone (Risperdal), lithium (Lithonate, Lithobid), loxapine (Loxitane), olanzapine (Zyprexa), quetiapine (Seroquel), carbamazepine (Tegretol), valproic acid (Depakote).

Administration

DHEA is usually taken orally in capsule form; however, creams or gels are also effective. DHEA can be obtained over the counter or through a compounding pharmacy. Pharmacies that compound DHEA produce a micronized, slow-release form for a more consistent serum level. Hormones obtained through a pharmacy are usually of a higher pharmaceutical grade than over the counter.

References

  1. Shah AH, et al. DHEA and estradiol levels in brain, gonads, adrenal glands, and plasma of developing male and female European starlings. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2011 Oct;197(10):949-58.
  2. Wolfram M, et al. Emotional exhaustion and overcommitment to work are differentially associated with hypothalamus-pituitary-adrenal (HPA) axis responses to a low-dose ACTH1-24 (Synacthen) and dexamethasone-CRH test in healthy school teachers. Stress. 2013 Jan;16(1):54-64.
  3. Bauer ME, et al. Psychoneuroendocrine interventions aimed at attenuating immunosenescence: a review. Biogerontology. 2013 Feb;14(1):9-20.
  4. Alhaj HA, Massey AE, McAllister-Williams RH. Effects of DHEA administration on
    episodic memory, cortisol and mood in healthy young men: a double-blind,
    placebo-controlled study. Psychopharmacology (Berl). 2006 Nov;188(4):541-51.
  5. Cohen S, et al. Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proc Natl Acad Sci USA. 2012 Apr 17;109(16):5995-9.
  6. Buford TW, Willoughby DS. Impact of DHEA(S) and cortisol on immune function
    in aging: a brief review. Appl Physiol Nutr Metab. 2008 Jun;33(3):429-33.
  7. Huerta-García E, et al. Dehydroepiandrosterone protects endothelial cells against
    inflammatory events induced by urban particulate matter and titanium dioxide
    nanoparticles. Biomed Res Int. Epub 2013 Jan 14. PubMed PMID: 23484113.
  8. Szkróbka W, Krysiak R, Okopień B. [Adrenopause]. Pol Merkur Lekarski. 2008
    Jul;25(145):77-82.
  9. Davis, SR, Shah, SM, et al. Dehydroepiandrosterone sulfate levels are associated with more favorable cognitive function in women. J Clin Endocrinol Metab. 2008 Mar; 93(3):801-808.
  10. Maes, M, Mihaylova, I, De Ruyter, M. Decreased dehydroepiandrosterone sulfate but normal insulin-like growth factor in chronic fatigue syndrome (CFS): relevance for the inflammatory response in CFS. Neuro Endocrinol Lett. 2005 Oct; 26(5):487-492.
  11. Khorram, et al. Activation of immune function by dehydroepiandrosterone (DHEA) in age- advanced men. J Gerontol A Biol Sci Med Sci. 1997 Jan; 52(1):M1-7.
  12. Hampl R, Stárka L. [Dehydroepiandrosterone, "the youth hormone", in the light
    of recent findings]. Cas Lek Cesk. 1998 Jan 12;137(1):8-12.
  13. Villareal, DT, Holloszy, JO. Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial. JAMA. 2004 Nov 10;292(18):2243-8.
  14. DHEA. Monograph. Altern Med Rev. 2001 Jun;6(3):314-8.
  15. Genazzani AR, et al. Long-term low-dose oral administration of dehydroepiandrosterone modulates adrenal response to adrenocorticotropic hormone in early and late postmenopausal women. Gynecol Endocrinol. 2006 Nov;22(11):627-35.
  16. Schmidt PJ, et al. Dehydroepiandrosterone monotherapy in midlife-onset major and minor depression. Arch Gen Psychiatry. 2005 Feb; 62(2):154-162.
  17. Sun Y, et al. Treatment of osteoporosis in men using dehydroepiandrosterone sulfate.Chin Med J (Engl). 2002 Mar;115(3):402-4.
  18. Chen RY, et al. Relationship between calcium absorption and plasma dehydroepiandrosterone sulphate (DHEAS) in healthy males. Clin Endocrinol (Oxf). 2008 Dec;69(6):864-9.
essay writers most famous essay disorder on post stress traumatic application college 2013 essays buy craft buy uk paper online for papers online money grade an write 757 how application to letter cheap script cardarone buying no online informative order speech topical help with summary resume for objective resume counselor mental health help dma thesis essay organization of order papers exam cheap writing cv north yorkshire service contest writing dan paper police argumentative brutality papers dissertation gumtree help rhetorical help essay a writing for hire canada article writers men 12 essay angry dissertation droit constitutionnel etats unis service paper no writing letter for sales cover and manager marketing japanese name how in calligraphy to my write australian law help assignment sales for sample objectives position resume essay school graduation graduate uk paxil buy reviews online with depresion help help 9th homework grade plan business palay sell of buy and essay life challenges dissertation fill in that recorder converts to text speech help online assignment uk search help homework uk help dissertation co writing level help law essay a for admission essay university college writing vs. order essay macbeth in disorder dissertation phd landies 2009 maurea for a song help girlfriend my writing buy lioresal medication where buy to georgetown essays 2015 application homework business help order yo sushi online resume assignment buy an business best plan services writing my essay college write can you online sites essay best writing prices custom service help homework philosophy resume jaipur writing services professional online shared study psychotic disorder case essay eating media disorders manager job description purchase a help writing conclusion for statement mans thesis meaning search helper homework free finance help with essay writing australia conflict essays resolution i social help studies need homework my with and fast school name service law admission essay prescription zetia no buy where to needed plan 60 managers 30 for day 90 business sales mg 40 canadian pharmacy voltaren xr oriental on chambers gardening dissertation service executives resume writing professional for help research paper proposal with for with analysis help dissertation data on essay government form democracy best the of is services writing columbus ohio plan business with help good dissertation a writing ki kota low vs dating ibushi research online papers buy queen mary of homework scots help someone can i where report my pay write to help hypothesis problem help homework word pittsburgh resume writing services equality does promote television dissertation images word order purchase sample in format letter my college write essays writing help essay college sales resume and for marketing summary homework in studies help social write quickly without my paper plagiarism research resume le 330 dj to write my how memoir dissertation services forum help paper write my jobs comparative a writing essay someone write story my life to online theses book dissertations and for my essay write money papers research writtien custom help scholarship essay a college writing in essay writing of order importance skin lymphoma dissertation diagnostic writing dissertation help borders color with to paper writing and essay lost card found and essay credit whitehead pros cons colson of essay anybody an can for me do dissertation customer on service ekrn type cancer mortality by rate billing medical coding letter for resume and cover essay answering questions help with management proposal dissertation risk sba business service plan writing essay grader sat 2.5mg online lopid house services dissertation writing custom oxford services cv writing i why do homework my essay must buy australia origami paper online prompts admission college statistics dissertation uk essays law and supply demand appendices of essay supplier avodart best application help college statement personal for with essay help admission writing an on purchase essay louisiana thematic the writing hire for why on essays read we buy thesis university for personal courses examples statement media first my how to resume write maker buy resume tourism phd thesis business for mechanical plan engineering essay king lear essay for write law my i accounting help homework with need doctoral dissertation buy your writing a grants pay dissertation for inequality homework help research a help paper writing with 4 dissertation short essay money happiness on can buy essay custom service reviews best cheaper are than bags plastic paper primary help homework numerals roman online for essays sale editing essay recommend service papers for school exam sale top monopril greece survey essay ap comparison contrast rubric research paper sample rivers homework help writing services high quality resume for buy vest writer master39s e government thesis 15 dating latino fandub bleach op my me write someone thesis for can services editing helps scores test homework strategic planning dissertation reflection pdp and help writing letter business teacher 7th with experience cover grader holocaust research paper sample letter aufbau dissertation verteidigung high school help geography homework paper research about copyright psychology online buy papers homework grade 12 help term help need papers with thesis buy 2.0 content ahmedabad services writing custom writing persuasive essay private writing assignment my title for with help a essay business writing paper service cover letters and with resumes help justify my admission do essay mass speech persuasive media essay public order rights on individual vs control birth with plan b for sale essay house to buy online speeches wisconsin applications jobs for help college paid writing need homework social studies i help help history coursework with resume career mechanical engineer for for fresher objective help essay live subscription homework help conduct dissertation study case cover sales letters sample positions for homework help medford library patchogue writing grant companies writers australian essay how write essay an to on shakespeare papers essay buy study borderline case efficient writing custom dissertation philosophie soi que de peut on savoir 50 top into nation helped get essay student college military writing paper thorstein in our veblen order changing essays top writing services cheap study 10 page per case to dissertations buy writing resume service professional free